Cranium is one of the best games out!! I love it! Xippy and I got it for a friend for xmas last year and its been well and truly used - especially on girls weekends
Its also really good for 5am Saturday/Sunday morning after a big night out ;-)
I'm a bit of a board game junkie I must admit - I have about 20 current board games plus a few boxes of vintage games from the 50's and 60's that I collect.
Another good one that Opranauts would be really good at is Baulderdash - its basically a challenge to see who can bullshit each other the best