Slam a new header on the top with better ads spots in it and leave the rest as is I say.. I like the colours of Oprano as they are... and like the way this script works much more than the Vbulliten sites... particularly the lastest version with all the javascripted drop down menu links.
Have you seen this plug-in for this board Guys?
http://www.invisionblog.com/
Sounds like it will handle the personal profile pages Nick spoke of and its only about 50 bucks I think.
and they also have this that integrates with existing member logins and lets everyone have a photoalbum.. or contribute to a joint one
http://www.invisiongallery.com/